Why cannabis can be a beneficial ingredient in lube Lube is important – but do you really need weed in it? Can’t you just smoke a joint and call it good? Sure, you could – and it may increase your pleasure. But did you know that your endocannabinoid system has receptors on the penis, vagina, labia, and clitoris? These receptors are activated in one of two ways: by endocannabinoids, and by cannabis. Topical cannabis applications like lube cut out the middle man (absorbing in your bloodstream) and deliver the ECS-stimulating cannabinoids directly to the intimate parts of your body, exactly where you want them. CBD and THC are vasodilators, which increase blood flow. Increasing blood flow is a crucial part of the arousal process- both the penis and vagina engorge with blood prior to sex. CBD and THC have dose-dependent anti-anxiety effects that can also help you relax. Being in a relaxed state of mind is important for sexual pleasure and reaching orgasm. CBD and THC are anti-inflammatory, which may reduce pain associated with sex, particularly for women.